Diazepam is a benzodiazepine derivative which possesses anxiolytic, anticonvulsant and muscle relaxant properties. Levetiracetam in sodium chloride injection is an antiepileptic drug indicated for adults 16 years and older with the following seizure types when oral administration is temporarily not feasible. A dilution of diazepam injection with propylene glycol containing 1 mgml has also been used. Phenobarbital sodium injection usp page 6 of 21 there were 43,892 patients treated in the placebo controlled clinical trials that were included in the metaanalysis. When used for continuous infusion, the emulsion may be added to dextrose 5% or 10% to make a solution with a concentration of 0. Description valium diazepam is a benzodiazepine derivative. Diazepam injection fda prescribing information, side. Dec 04, 2019 in animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Lorazepam injection, usp civ 40 mg10 ml 4 mgml 10 x 10 ml multiple dose vialsndc. The chemical name of diazepam is 7chloro1,3dihydro1methyl5phenyl2h1,4benzodiazepin 2one. Diazepam injection, usp concomitant use of barbiturates.
Diazepam injection, usp, is a solution containing diazepam, a benzodiazepine used to relieve anxiety and provide sedation. Includes dosages for anxiety, muscle spasm, seizures and more. Read the package insert and instructions for use that come with this drug. Emergency compounding of an oral suspension from tamiflu capsules. The patient package insert and oral dispenser should be. How supplied diazepam oral solution, 5 mg per 5 ml orangecolored, wintergreenspice flavored solution ndc 0054820716. The drug should be used with caution in patients with coronary. Diazepam is a useful premedication the intramuscular route is preferred for relief of anxiety and tension in patients who are to undergo surgical procedures.
Any health care professional who intends to treat a patient with status epilepticus should be familiar with this package insert and the pertinent medical literature concerning current concepts for the treatment of status epilepticus. Information for the user midazolam 2 mgml solution for injection or infusion midazolam 5 mgml solution for injection or infusion midazolam as midazolam hydrochloride read all of this leaflet carefully before you start using this medicine because it contains important information for you. Ativan lorazepam injection rx only description lorazepam, a benzodiazepine with antianxiety, sedative, and anticonvulsant effects, is intended for the intramuscular or intravenous routes of administration. Highlights of prescribing information these highlights do not include all the information needed to use cubicin safely and effectively. In addition to the active ingredient diazepam, each tablet contains the following inactive ingredients. Oral diazepam tablets are contraindicated for use in patients with severe respiratory insufficiency or sleep apnea syndrome. Medscape prescription drug monographs are based on fda approved.
Diazepam injection is contraindicated in patients with a known hypersensitivity to this drug. Diastat acudial can control a prolonged breakthrough seizure. Chapter 37 compatibility and stability of drug products and preparations 685 figure 37. Midazolam was actively selfadministered in primate models used to assess the positive reinforcing effects of psychoactive drugs. Use extreme care when administering diazepam in patients with limited pulmonary reserve or compromised respiratory function related to concurrent pulmonary disease process e. Supporting documents older than three years hespan 6% hetastarch in 0. Gently insert the nozzle tip into the nostril until the fingers on either side of. Risk of medication errors and hepatotoxicity see full prescribing information for complete boxed warning take care when prescribing, preparing, and administering ofirmev injection to avoid dosing errors which could result in accidental overdose and death. Intravenous midazolam injection has been associated with respiratory depression and respiratory arrest, especially when used for sedation in noncritical care settings.
Review package insert for diastat rectal gel with patient caregiver prior to administration. When diazepam is used with a narcotic analgesic, the dosage of the narcotic. Valium, diastat diazepam dosing, indications, interactions, adverse. See full prescribing information for complete boxed warning. Haloperidol injection, usp is available as a sterile parenteral form for intramuscular injection. Lorazepam injection usp is useful as an initial anticonvulsant medication for the control of status epilepticus. Highlights of prescribing information these highlights do not include all the information needed to use. The complete flumazenil package insert including contraindications, warnings, and precautions should be. Each vial of midazolam injection 5mgml contains 8 mgml sodium. Diastat acudial is an athome medication for patients 2 years of age and older on stable antiepileptic drugs aeds who require occasional use of diazepam to control bouts of increased seizure activity or prolonged breakthrough seizures increased seizure activity. Diazepam oral solution 5 mg per 5 ml diazepam intensol tm. Sep 01, 2019 the complete flumazenil package insert including contraindications, warnings, and precautions should be consulted prior to use. Medscape prescription drug monographs are based on fdaapproved.
If you have further questions, ask your doctor, pharmacist or nurse. Diazepam fda prescribing information, side effects and uses. Assival acts on parts of the limbic system, the thalamus and hypothalamus, and. Taxol paclitaxel injection is a clear, colorless to slightly yellow viscous solution. Each ml of this sterile injection contains 5 mg diazepam compounded with 40% propylene glycol, 10% alcohol, 5% sodium benzoate and benzoic acid as buffers, and 1. Diazepam oral solution 5 mg per 5 ml diazepam intensol. Intravenous fluids should be administered and an adequate airway maintained. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects. Angiomax is intended for intravenous bolus injection and continuous infusion after reconstitution and dilution.
Special precautions no special precautions required for hazard control. Product monograph pr milrinone lactate injection 1 mgml milrinone usp. It is supplied as a nonaqueous solution intended for dilution with a suitable parenteral fluid prior to intravenous infusion. This drug may cause tissue damage if the drug leaks from the vein. Diazepam injection diazepam dose, indications, adverse. Once the acute symptomatology has been properly controlled with diazepam injection, transition the patient to oral diazepam therapy if further treatment is required.
Dailymed midazolam hydrochloride injection, solution. Highlights of prescribing information age group dosage. Fluphenazine decanoate injection, usp package insert. Diazepam oral solution 5 mg per 5 ml diazepam intensol tm oral solution concentrate 5 mg per ml description each 5 ml of oral solution contains.
Fda package insert until additional information is available, diazepam injection is not recommended for obstetrical use. The complete flumazenil package insert including contraindications, warnings, and precautions should be consulted prior to use. Phenobarbital sodium injection usp page 1 of 21 prescribing information phenobarbital sodium injection usp 30 mgml, 120 mgml therapeutic classification anticonvulsant, hypnotic, sedative barbiturate sandoz canada inc. Do not inject into areas of lipodystrophy or localized. Warnings concomitant use of benzodiazepines, including diazepam, and opioids may result in profound sedation, respiratory depression, coma, and death. To reduce the risk of lipodystrophyand localized cutaneous amyloidosis, rotate the injection site within the same region from one injection to the next. Product monograph midazolam injection usp preservativefree page 5 of 39. Each ml contains 5 mg haloperidol as the lactate with 1. Prescribers should regularly discuss the caregiver administration instructions found in the package insert with the caregiver and patient. Cytarabine injection, an antineoplastic, is a sterile solution of cytarabine for intravenous and subcutaneous use which contains no preservative and is available in 20 mgml mg50 ml pharmacy bulk package.
Injection should be closely monitored during infusion. Detailed diazepam dosage information for adults, the elderly and children. Midazolam produced physical dependence of a mild to moderate intensity in cynomolgus monkeys after 5 to 10 weeks of administration. Feb 01, 2020 diazepam is available for oral administration as tablets containing 2 mg, 5 mg or 10 mg diazepam. Nexterone amiodarone hydrochloride injection, solution baxter healthcare corporationhighlights of prescribing information these highlights do not include all the information needed to use nexterone safely and effectively. If infusion is selected, adding the infusion solution to the diazepam injection and not. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Primacor milrinone lactate injection 200 mcgml in 5% dextrose injection description primacor, brand of milrinone lactate injection, is a member of a class of bipyridine inotropicvasodilator agents with phosphodiesterase inhibitor activity, distinct from digitalis glycosides or catecholamines. Approximately 75% of patients in these clinical trials were treated for indications other than epilepsy and, for the majority of nonepilepsy indications the treatment. Diazepam injection usp is indicated when a rapid response to the use of. As an adjunct prior to endoscopic procedures if apprehension, anxiety or acute stress reactions are present, and to diminish the patients recall of the procedures.
Valium is available for oral administration as tablets containing 2 mg, 5. It is a colorless to light yellow crystalline compound, insoluble in water. Doses of 8 mg to 10 mg of intravenous lorazepam 2 to 212 times the maximum recommended dosage will produce loss of lid reflexes within 15 minutes. Midazolam injection is a sterile, isotonic, clear, colourless to pale yellow solution in areadyto use, single dose presentation. Baxter healthcare corporation nexterone amiodarone. Diazepam injection is a sterile solution packaged within a device that delivers its.
Diazepam injection, usp 10 mg2 ml is a clear, colorless to slightly yellow solution supplied in 2 ml prefilled sterile singledose syringe with luer lock. Jul 24, 2019 midazolam injection contains midazolam a schedule iv control substance. The infusion rate to be administered should be selected from the righthand column in table 1. Medscape antianxiety, antiseizurespecific dosing for valium, diastat. Clinically employed doses of ativan injection do not greatly affect the circulatory system in the supine position or employing a 70degree tilt test. As the safety of vimpat injection in pediatric patients has not been established, vimpat injection is indicated for the treatment of partialonset seizures only in adult patients 17 years of age and older. Hazards identification emergency overview diazepam injection, usp, is a solution containing diazepam, a benzodiazepine used to relieve anxiety and provide sedation. Next, withdraw and discard 5 ml from a 50 ml infusion bag containing 5% dextrose in water or 0. Stability and compatibility study of parenteral diazepam.
Valium is a useful adjunct for the relief of skeletal muscle spasm due to reflex spasm to local pathology, such as inflammation of the muscle and joints or secondary to trauma. Valium injection should not be used during pregnancy except if absolutely necessary. Fluphenazine decanoate injection, usp package insert one can expect a higher incidence with fluphenazine decanoate than with less potent piperazine derivatives or with straightchain phenothiazines such as chlorpromazine. Fentanyl citrate injection is a sterile, nonpyrogenic, preservative free aqueous solution for intravenous or intramuscular injection. The pi is different from the patient package insert ppi, which contains information intended for patients, notwithstanding that the ppi may be required as part of the fdaapproved labeling for the drug. Each reconstituted vial should be further diluted in 500 ml of 5% dextrose in water or 0. Propylene glycol, alcohol, sodium benzoate, benzyl alcohol, benzoic acid, water for injection. Tasigna nilotinib capsules, for oral use initial u. With any given phenothiazine derivative, the incidence and severity of such. Diazepam injection has produced hypotension or muscular weakness in some patients particularly when used with narcotics, barbiturates, or alcohol. Pdf compatibility and stability of drug products and. Dexamethasone sodium phosphate injection, 10 mgml for intravenous and intramuscular injection only. The complete flumazenil package insert including contraindications, warnings, and precautions.
The com plete flumazenil package insert including contraindications, warnings. Diazepam this information from lexicomp explains what you need to know about this. Diazepam injection should be used in those patients with caution and in low doses to preclude development of ataxia, sedation and other possible adverse effects. Clinical pharmacology fentanyl citrate is a narcotic analgesic. Valium tablets r only food and drug administration. Diazepam injection is a useful adjunct in status epilepticus and severe recurrent convulsive seizures. No clinical studies have been conducted in patients in the acute phase of postmyocardial. To each 250 mg vial, add 5 ml of sterile water for injection, usp. Cubicin daptomycinfor injection,for intravenous use initial u. Diazepam injection, usp synonyms 7chloro1,3dihydro1methyl5phenyl2h1,4benzodiazepin2one 2. Diazepam and its metabolites are highly bound to plasma proteins diazepam 98%. Oral ld50 of diazepam is 720 mgkg in mice and 1240 mgkg in rats. Diazepam injection diazepam dose, indications, adverse effects.
Diazepam injection has been used for rectal administration. When diazepam is used with a narcotic analgesic, the dosage of the narcotic should be reduced by at least onethird and administered in small increments. Labeled dose range of 1 to 10 mgkg with a maximum cumulative dose of 10 mgkg. Fda package insert when given intramuscularly, lorazepam injection, undiluted, should be injected deep in the muscle mass. May 15, 2015 the pi is different from the patient package insert ppi, which contains information intended for patients, notwithstanding that the ppi may be required as part of the fdaapproved labeling for the drug. Diazepam injection, usp is a sterile, nonpyrogenic solution intended for intramuscular or intravenous administration.
Benzodiazepines are one of the most commonly prescribed medications to treat anxiety, insomnia, and other conditions in the united states. Ddavp injection desmopressin acetate 4 mcgml has infrequently produced changes in blood pressure causing either a slight elev ation in blood pressure or a transient fall in blood pressure and a compensatory increase in heart rate. Tamiflu oseltamivir phosphate capsules and for oral. Contraindications lorazepam injection usplorazepamis contraindicated in patients with myasthenia gravis or acute narrow angle glaucoma, and in those with known hypersensitivity to benzodiazepines. Information for the user midazolam 2 mgml solution for injection or infusion midazolam 5 mgml solution for injection or infusion midazolam as midazolam hydrochloride read all of this leaflet carefully before you start using this medicine because it contains. Unit dose patient cup tm filled to deliver 5 ml diazepam 5 mg, ten 5 ml patient cups per shelf pack, 4 shelf packs per shipper. Stability and compatibility study of parenteral diazepam in. Prior to tasigna administration and periodically, monitor for hypokalemia or hypomagnesemia and correct deficiencies. Read all of this leaflet carefully before you start this medicinebecause it contains using important information for you. Find patient medical information for diazepam injection on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Depakene valproic acid is indicated for use as sole and adjunctive therapy in the treatment of simple and complex absence seizures, and adjunctively in patients with multiple. The clearance of diazepam and certain other benzodiazepines can be delayed in association with tagamet cimetidine administration. Alcohol,antidepressants antihistamines, and opioidanalge.
Highlights of prescribing information these highlights do not include all the information needed to use tasignasafely and effectively. As the safety of vimpat injection in pediatric patients has not been established, vimpat injection is indicated for the treatment of partialonset. Diazepam and its metabolites cross the bloodbrain and placental barriers and are also found in breast milk in concentrations approximately one tenth of those in maternal plasma days 3 to 9 postpartum. Dexamethasone sodium phosphate injection can be given directly from the vial, or it can be added to sodium chloride injection or dextrose injection and administered by intravenous drip.